I have not read the book so I can not compare the two (though I have read up on some of the differences). I can say that the movie is pretty good. I went to it with some friends, kleenex in pocket, and we prepared to cry over the sad cancer story.
While nothing was particularly surprising in the movie (except maybe that I didn't cry as much as others or as much as I thought I would) it was enjoyable to watch. Enjoyable in the sense that it was incredibly sad and well acted. Cameron Diaz played the mom who just couldn't accept her daughter's fate. Sofia Vassilieva, who played the dying daughter Kate, was also really good in her role. Of course Abigail Breslin was excellent as ever.
My Sister's Keeper gets two stars - a family tragedy that is enjoyable to watch but not overly original.
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